Evolution of ambulatory measurement of blood pressure and parameters of arterial stiffness over a 1-year period in patients with systemic sclerosis: ERAMS study.
J Hum Hypertens. 2002-09-01; 16(9): 627-630
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1. J Hum Hypertens. 2002 Sep;16(9):627-30.
Evolution of ambulatory measurement of blood pressure and parameters of arterial
stiffness over a 1-year period in patients with systemic sclerosis: ERAMS study.
Gosse P(1), Taillard J, Constans J; ERAMS Study Investigators.
(1)Service de Cardiologie et Hypertension Artérielle et Service de Médecine
Interne et Pathologie Vasculaire, Hôpital Saint-André, 1 rue Jean Burguet, 33075
Bordeaux, France. *protected email*
Patients with systemic sclerosis commonly exhibit increased arterial stiffness,
which may be predictive of the overall severity of the disease. The aim of the
present study was to check the stability of parameters of arterial stiffness
after 1 year in this population. ERAMS is a French multicentric prospective study
designed to identify a link between arterial distensibility and outcome in 100
patients with systemic sclerosis. Arterial distensibility was evaluated by 24-h
ambulatory monitoring of QKD interval along with blood pressure (BP) and heart
rate (HR) (four measurements/hour). The index QKD(100-60), which is linked to
aortic distensibility, was calculated automatically. QKD(100-60) is the value of
QKD (which depends on pulse wave velocity) for 100 mm Hg sBP and 60 bpm HR. The
reproducibility of QKD(100-60) was assessed on the first patients to be followed
up for a complete year. So far the 100 patients have been recruited from 14
participating centres and 48 were re-evaluated after 1 year. QKD(100-60) was
highly reproducible: 201 +/- 6 vs202 +/- 18 msec, standard deviation of
difference = 13 msec.IN CONCLUSION: determination of QKD(100-60) to assess
arterial stiffness gives stable results over 1 year in patients with systemic
PMID: 12214258 [Indexed for MEDLINE]