Evidence for addiction-like behavior in the rat.

V. Deroche-Gamonet, D. Belin, P.V. Piazza
Science. 2004-08-13; 305(5686): 1014-1017
DOI: 10.1126/science.1099020

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Deroche-Gamonet V(1), Belin D, Piazza PV.

Author information:
(1)INSERM U588, Laboratoire de Physiopathologie des Comportements, Bordeaux
Institute for Neurosciences, University Victor Segalen-Bordeaux 2, Domaine de
Carreire, Rue Camille Saint-Saëns, 33077 Bordeaux Cedex, France.

Comment in
Science. 2004 Aug 13;305(5686):951-3.

Although the voluntary intake of drugs of abuse is a behavior largely preserved
throughout phylogeny, it is currently unclear whether pathological drug use
(« addiction ») can be observed in species other than humans. Here, we report that
behaviors that resemble three of the essential diagnostic criteria for addiction
appear over time in rats trained to self-administer cocaine. As in humans, this
addiction-like behavior is present only in a small proportion of subjects using
cocaine and is highly predictive of relapse after withdrawal. These findings
provide a new basis for developing a true understanding and treatment of

DOI: 10.1126/science.1099020
PMID: 15310906 [Indexed for MEDLINE]

Auteurs Bordeaux Neurocampus