Evaluation of anti-secretory and anti-ulcerogenic activities of Avipattikar Churna on the peptic ulcers in experimental rats
1. J Clin Diagn Res. 2013 Jun;7(6):1135-9. doi: 10.7860/JCDR/2013/5309.3058. Epub
2013 Jun 1.
Evaluation of anti-secretory and anti-ulcerogenic activities of avipattikar
churna on the peptic ulcers in experimental rats.
Gyawali S(1), Khan GM, Lamichane S, Gautam J, Ghimire S, Adhikari R, Lamsal R.
(1)Assistant Professor, Department of Pharmacology, Manipal College of Medical
Sciences (MCOMS) , Deepheight, Pokhara, Nepal .
BACKGROUND: Avipattikar churna, a poly-herbal formulation, is one of the popular
ayurvedic formulations which is used for peptic ulcer diseases but the scientific
documentation with regards to its effect for the indication is lacking.
AIMS: This study was carried out to evaluate the anti-secretory and the
anti-ulcerogenic activities of the churna and to compare its activity with that
of ranitidine in a pyloric ligated model of rats.
MATERIAL AND METHODS: Four groups of rats with 6 animals in each served as the
ulcer controls, churna low dose (500 mg/kg), churna high dose (750mg/kg) and
ranitidine (25mg/kg). The control group rats received only vehicle (2% (v/v) gum
acacia), while the rats of the other groups received the respective dose of the
churna or ranitidine which was suspended in the vehicle. The treatments were
given twice a day, orally, for two days. After 1 hour of the last dose, pyloric
ligations were performed and the rats were sacrificed for evaluation after four
hours of the ligations. The gastric contents were collected and its volume, pH
and acidity were measured. The numbers of ulcers and their lengths were measured
which were used to calculate the gastric irritancy index and the curative ratio.
The histological examinations of the gastric tissues were also performed.
RESULTS: The churna, in both doses, significantly decreased the volumes of the
gastric contents, the ulcer score, the length of the ulcer, the gastric irritancy
index and pH increased as compared to those in the control group. The effects of
the churna were comparable to that of ranitidine. The histopathological
evaluation of the gastric tissue also supported the results.
CONCLUSION: Avipattikar churna has anti-secretory and anti-ulcerogenic effects
which are comparable to those of ranitidine in peptic ulcer diseases.