Evaluation of adherence patterns in schizophrenia using electronic monitoring (MEMS®): A six-month post-discharge prospective study.
Schizophrenia Research. 2018-03-01; 193: 114-118
DOI: 10.1016/j.schres.2017.06.026
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1. Schizophr Res. 2018 Mar;193:114-118. doi: 10.1016/j.schres.2017.06.026. Epub
2017 Jun 26.
Evaluation of adherence patterns in schizophrenia using electronic monitoring
(MEMS®): A six-month post-discharge prospective study.
Misdrahi D(1), Tessier A(2), Husky M(3), Lange AC(4), Vrijens B(5), Llorca
PM(6), Baylé FJ(7).
Author information:
(1)Centre Hospitalier Charles Perrens, CNRS UMR 5287-INCIA, Université de
Bordeaux, BP-33076 Bordeaux, France. Electronic address:
.
(2)Centre Hospitalier Charles Perrens, CNRS UMR 5287-INCIA, Université de
Bordeaux, BP-33076 Bordeaux, France. Electronic address: .
(3)Université de Bordeaux, Laboratoire de Psychologie EA4139, Institut
Universitaire de France, 33000 Bordeaux, France. Electronic address:
.
(4)WestRock Healthcare, Sion, Switzerland, Department of Biostatistics and
Medical Informatics, University of Liège, Liège, Belgium. Electronic address:
.
(5)WestRock Healthcare, Sion, Switzerland, Department of Biostatistics and
Medical Informatics, University of Liège, Liège, Belgium. Electronic address:
.
(6)CMP B, CHU, EA 7280 Faculté de Médecine, Université d’Auvergne, BP 69 63003
Clermont-Ferrand Cedex 1, France. Electronic address:
.
(7)Sainte-Anne Hospital (SHU), Paris V-Descartes University, Paris, France.
Electronic address: .
BACKGROUND: Medication Event Monitoring System (MEMS®) is considered the gold
standard for the evaluation of medication adherence, yet few studies have
applied this method, especially over long periods of time.
OBJECTIVE: To investigate medication adherence patterns in a sample of
post-discharge patients with schizophrenia monitored with MEMS caps during a
six-month period.
METHOD: Adherence to antipsychotics was prospectively investigated using MEMS
among 68 patients with schizophrenia. Treatment initiation, implementation or
whether or not the patient takes his dosing regimen as prescribed, persistence
or the length of time between initiation and discontinuation, and treatment
discontinuation were used to describe adherence. Persistence over time was
described using Kaplan-Meier curves.
RESULTS: After discharge 16% of the patients never initiated treatment. On
average 37.3% of patients adhered to treatment in the first 6months. However, a
strong decrease in adherence was observed over time (p