Epidemiology, environmental risk factors and genetics of Parkinson’s disease | Épidémiologie, facteurs de risque environnementaux et génétiques de la maladie de Parkinson

Anna Delamarre, Wassilios G. Meissner
La Presse Médicale. 2017-03-01; 46(2): 175-181
DOI: 10.1016/j.lpm.2017.01.001

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1. Presse Med. 2017 Mar;46(2 Pt 1):175-181. doi: 10.1016/j.lpm.2017.01.001. Epub
2017 Feb 8.

Epidemiology, environmental risk factors and genetics of Parkinson’s disease.

Delamarre A(1), Meissner WG(2).

Author information:
(1)CHU de Bordeaux, hôpital Pellegrin, service de neurologie, 33000 Bordeaux,
France.
(2)CHU de Bordeaux, hôpital Pellegrin, service de neurologie, 33000 Bordeaux,
France; CHU de Bordeaux, hôpital Pellegrin, centre de référence maladie rare AMS,
33076 Bordeaux, France; University de Bordeaux, Institut des Maladies
Neurodégénératives, UMR 5293, 33000 Bordeaux, France; Institut des maladies
neurodégénératives, UMR 5293, CNRS, 33000 Bordeaux, France. Electronic address:
.

Parkinson’s disease (PD) is a frequent neurodegenerative disease with a premotor
phase that lasts several years. Risk factors that have been linked to PD are
tobacco, caffeine, black tea, pesticides and calcium channel blockers. Some risk
factors may be due to inverse causality (e.g. changes in personality during the
premotor phase). The genetics of PD are complex with a contribution of Mendelian
(e.g. SNCA, LRRK2, Parkin, Pink1,…) and non-Mendelian factors (e.g. single
nucleotide polymorphisms). Glucocerebrosidase gene mutations (Gaucher disease)
are currently the strongest genetic risk factor for PD. Studying risk factors
will help to better understand the pathogenesis of PD.

Copyright © 2017 Elsevier Masson SAS. All rights reserved.

DOI: 10.1016/j.lpm.2017.01.001
PMID: 28189372 [Indexed for MEDLINE]

Auteurs Bordeaux Neurocampus