Entorhinal cortex and cognition
Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2009-08-01; 33(5): 753-761
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1. Prog Neuropsychopharmacol Biol Psychiatry. 2009 Aug 1;33(5):753-61. doi:
10.1016/j.pnpbp.2009.03.038. Epub 2009 Apr 17.
Entorhinal cortex and cognition.
Coutureau E(1), Di Scala G.
(1)Centre de Neurosciences Intégratives et Cognitives, UMR 5228 CNRS, Universités
de Bordeaux 1 & 2, Avenue des Facultés, 33405 Talence, France.
Understanding the function of the entorhinal cortex (EC) has been an important
subject over the years, not least because of its cortical intermediary to and
from the hippocampus proper, and because of electrophysiological advances which
have started to reveal the physiology in behaving animals. Clearly, a lot more
needs to be done but is clear to date that EC is not merely a throughput station
providing all hippocampal subfields with sensory information, but that processing
within EC contributes significantly to attention, conditioning, event and spatial
cognition possibly by compressing representations that overlap in time. These are
transmitted to the hippocampus, where they are differentiated again and returned
to EC. Preliminary evidence for such a role, but also their possible pitfalls are
PMID: 19376185 [Indexed for MEDLINE]