Endocannabinoid control of food intake and energy balance

1. Nat Neurosci. 2005 May;8(5):585-9. doi: 10.1038/nn1457.

Endocannabinoid control of food intake and energy balance.

Di Marzo V(1), Matias I.

Author information:
(1)Endocannabinoid Research Group, Institute of Biomolecular Chemistry,
Consiglio Nazionale delle Ricerche, Via Campi Flegrei 34, 80078, Pozzuoli,
Naples, Italy.

Marijuana and its major psychotropic component, Delta(9)-tetrahydrocannabinol,
stimulate appetite and increase body weight in wasting syndromes, suggesting
that the CB(1) cannabinoid receptor and its endogenous ligands, the
endocannabinoids, are involved in controlling energy balance. The
endocannabinoid system controls food intake via both central and peripheral
mechanisms, and it may also stimulate lipogenesis and fat accumulation. Here we
discuss the multifaceted regulation of energy homeostasis by endocannabinoids,
together with its applications to the treatment of eating disorders and
metabolic syndromes.

DOI: 10.1038/nn1457
PMID: 15856067 [Indexed for MEDLINE]

Auteurs Bordeaux Neurocampus