Embryonic emergence of the respiratory rhythm generator
Respiratory Physiology & Neurobiology. 2009-08-01; 168(1-2): 86-91
DOI: 10.1016/j.resp.2009.06.013
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1. Respir Physiol Neurobiol. 2009 Aug 31;168(1-2):86-91. doi:
10.1016/j.resp.2009.06.013. Epub 2009 Jun 26.
Embryonic emergence of the respiratory rhythm generator.
Fortin G(1), Thoby-Brisson M.
Author information:
(1)Neurobiologie Génétique et Intégrative, Institut de Neurobiologie Alfred
Fessard, CNRS UPR2216, 91198 Gif sur Yvette, France.
Breathing is vital for life ex utero and therefore requires that the respiratory
rhythm generator (RRG), the central neural network generating the continuous
rhythmic motor command, be functional at birth. The RRG, located in the
brainstem, appears to comprise two interacting respiratory oscillators: the
parafacial respiratory group (pFRG), and the preBötzinger complex (preBötC). Data
on the establishment of these respiratory oscillators during embryonic and foetal
periods are beginning to be produced. The present paper provides a short review
of the current knowledge regarding: (i) the emergence of activity in the two
respiratory oscillators and (ii) their functional coupling during prenatal
development in rodents.
DOI: 10.1016/j.resp.2009.06.013
PMID: 19560563 [Indexed for MEDLINE]