Effects of riluzole on combined MPTP + 3-nitropropionic acid-induced mild to moderate striatonigral degeneration in mice
J Neural Transm. 2004-10-22; 112(5): 613-631
DOI: 10.1007/s00702-004-0206-z
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https://www.bordeaux-neurocampus.fr/12629
Diguet E(1), Fernagut PO, Scherfler C, Wenning G, Tison F.
Author information:
(1)Physiologie et Physiopathologie de la Signalisation Cellulaire, UMR-CNRS
5543, Université Victor Segalen-Bordeaux2, Bordeaux, France.
We investigated the potency of riluzole, an anti-glutamatergic drug, to affect
ongoing neuronal death process following combined MPTP + 3-nitropropionic acid
(3-NP) intoxication producing combined striatal and nigral degeneration (SND) in
mice. We used a « neuronal rescue » strategy by administering riluzole after the
end of intoxication. The motor disorder, its recovery, behavioral performances
at motor and sensorimotor integration tasks and histopathological outcome were
compared in the saline and riluzole groups (10 mg/kg and 20 mg/kg), matched by
triplets for motor severity. While riluzole did not produce any effect on the
gross motor disorder nor on rotarod task, open-field kinetic variables or on the
traversing beam task, it had a subtle effect on the performances at the pole
test. The histopathological outcome was significantly better in the
riluzole-treated mice regarding both nigral and dorsolateral striatal cell loss
and astroglial activation, with a dose-effect relationship. Thus, riluzole has
limited « neuronal rescue » properties from an histopathological point of view
with a subtle motor behavior improvement in a MPTP + 3-NP-induced SND in mice.
DOI: 10.1007/s00702-004-0206-z
PMID: 15503195 [Indexed for MEDLINE]