Effects of glia metabolism inhibition on nociceptive behavioral testing in rats

Yan Lefèvre, Aurélie Amadio, Peggy Vincent, Amélie Descheemaeker, Stéphane H.R. Oliet, Radhouane Dallel, Daniel L. Voisin
Data in Brief. 2016-06-01; 7: 372-375
DOI: 10.1016/j.dib.2016.02.043

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1. Data Brief. 2016 Feb 26;7:372-5. doi: 10.1016/j.dib.2016.02.043. eCollection 2016

Effects of glia metabolism inhibition on nociceptive behavioral testing in rats.

Lefèvre Y(1), Amadio A(1), Vincent P(1), Descheemaeker A(2), Oliet SH(1), Dallel
R(2), Voisin DL(1).

Author information:
(1)Neurocentre Magendie, Inserm U1215, F-33000 Bordeaux, France; Univ. Bordeaux,
F-33000 Bordeaux, France.
(2)Clermont Université, Université d׳Auvergne, NEURO-DOL, BP 10448, F-63000
Clermont-Ferrand, France; Inserm, U1107, F-63001 Clermont-Ferrand, France.

Fluoroacetate has been widely used to inhibit glia metabolism in vivo. It has yet
to be shown what the effects of chronic intrathecal infusion of fluoroacetate on
nociceptive behavioral testing are. The effects of chronic infusion of
fluoroacetate (5 nmoles/h) for 2 weeks were examined in normal rats. Chronic
intrathecal fluoroacetate did not alter mechanical threshold (von Frey
filaments), responses to supra-threshold mechanical stimuli (von Frey filaments),
responses to hot (hot plate) or cool (acetone test) stimuli and did not affect
motor performance of the animals, which was tested with rotarod. This suggests
that fluoroacetate at appropriate dose did not suppress neuronal activity in the
spinal cord.

DOI: 10.1016/j.dib.2016.02.043
PMCID: PMC4781975
PMID: 26977440

Auteurs Bordeaux Neurocampus