Effects of acute or chronic administration of risperidone on motor and sexual behavior of male rats.
Pharmacological Research. 1997-01-01; 35(1): 17-25
DOI: 10.1006/phrs.1996.0101
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1. Pharmacol Res. 1997 Jan;35(1):17-25.
Effects of acute or chronic administration of risperidone on motor and sexual
behavior of male rats.
Drago F(1), Contarino A, Marino R, Anzallo C, Valerio C, Rampello L, Raffaele R,
Scapagnini U.
Author information:
(1)Institute of Pharmacology, University of Catania Medical School, Italy.
A number of experiments were carried out to explore the behavioral profile of a
novel antipsychotic, risperidone, after acute or chronic administration, in a
dose range of 0.1-10 mg kg-1. This drug did not affect the acquisition and
retention of avoidance behaviors in a dose of 0.1 mg kg-1, either after acute or
chronic administration. Higher doses induced a inhibited acquisition and a
facilitated extinction (only after chronic treatment) of active avoidance
behavior, but no significant effect on the retention of passive avoidance
responses. In contrast, haloperidol inhibited the acquisition and facilitated the
extinction of active avoidance behavior, and reduced the retention of passive
avoidance reaction at the dose of 0.1 mg kg-1 injected either acutely or
chronically. Ambulation and rearing of rats rated in an open field was increased
by risperidone injected acutely at the dose of 1 mg kg-1. Under the same
experimental conditions, grooming appeared to be reduced. In the same test, acute
or chronic haloperidol 1 or 10 mg kg-1 inhibited all behavioral items.
Furthermore, in contrast to haloperidol, the acute or chronic administration of
risperidone in a dose range of 0.1-10 mg kg-1 did not substantially induce
catalepsy and did not affect apomorphine-induced stereotypies. Also, the dose of
0.1 mg kg-1 induced a facilitation of male sexual behavior by increasing the
frequency and reducing the latency of mountings, intromissions and ejaculations,
while haloperidol 1 or 10 mg kg-1 inhibited this behavior. These findings suggest
that the pharmacological profile of risperidone differs from that of classical
neuroleptics, like haloperidol, probably due to different mechanism or site of
action.
DOI: 10.1006/phrs.1996.0101
PMID: 9149311 [Indexed for MEDLINE]