Effector-dependent neglect and splenial disconnection: a spherical deconvolution tractography study

Marine Lunven, Michel Thiebaut De Schotten, Bertrand Glize, Raffaella Migliaccio, Sophie Jacquin-Courtois, François Cotton, Paolo Bartolomeo, Gilles Rode
Exp Brain Res. 2014-08-13; 232(12): 3727-3736
DOI: 10.1007/s00221-014-4051-5

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1. Exp Brain Res. 2014 Dec;232(12):3727-36. doi: 10.1007/s00221-014-4051-5. Epub
2014 Aug 13.

Effector-dependent neglect and splenial disconnection: a spherical deconvolution
tractography study.

Lunven M(1), Thiebaut De Schotten M, Glize B, Migliaccio R, Jacquin-Courtois S,
Cotton F, Bartolomeo P, Rode G.

Author information:
(1)Inserm UMR_S 1028, CNRS UMR 5292, ImpAct, Centre des Neurosciences de Lyon,
Université Lyon-1, 16, Avenue Lépine, 69676, Bron, France,

We present the case of a patient with left homonymous hemianopia and chronic left
neglect consequent to a stroke in the occipito-temporal regions of the right
hemisphere. When the patient performed cancellation tasks with her right
(dominant) hand, she had severe and persistent left neglect at retest 7 and 8
years after onset. However, her performance on line bisection was invariably
within normal limits. Strikingly, performance on cancellation tests reverted to
normal when the patient used her left hand. White matter tractography using
spherical deconvolution demonstrated damage to the splenium of the corpus
callosum, as well as a relative preservation of the right fronto-parietal
network. Effector-dependent neglect may occur because splenial disconnection
deprives the right fronto-parietal network from visual information processed by
the left hemisphere. Consequently, spatial exploration reverts to normal when the
patient uses her left hand, thus involving more directly the fronto-parietal
attentional networks in the right-hemisphere.

DOI: 10.1007/s00221-014-4051-5
PMID: 25116649 [Indexed for MEDLINE]

Auteurs Bordeaux Neurocampus