Effect of a high-fat–high-fructose diet, stress and cinnamon on central expression of genes related to immune system, hypothalamic-pituitary-adrenocortical axis function and cerebral plasticity in rats.
Br J Nutr. 2013-11-20; 111(07): 1190-1201
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1. Br J Nutr. 2014 Apr 14;111(7):1190-201. doi: 10.1017/S0007114513003577. Epub 2013
Effect of a high-fat–high-fructose diet, stress and cinnamon on central
expression of genes related to immune system,
hypothalamic-pituitary-adrenocortical axis function and cerebral plasticity in
Marissal-Arvy N(1), Batandier C(2), Dallennes J(1), Canini F(3), Poulet L(3),
Couturier K(2), Hininger-Favier I(2), Moisan MP(1), Roussel AM(2), Mormède P(1).
(1)INRA, Laboratory of Nutrition and Integrative Neurobiology, UMR 1286, Pharmacy
Building 2nd Floor, 33076 Bordeaux Cedex, France.
(2)LBFA/INSERM, U1055, BP 53X, 38041 Grenoble Cedex, France.
(3)IRBA-CRSSA, Unité de Neurophysiologie du stress, 38702 La Tronche Cedex,
Br J Nutr. 2014 Jun 14;111(11):2044.
The intake of a high-fat/high-fructose (HF/HFr) diet is described to be
deleterious to cognitive performances, possibly via the induction of inflammatory
factors. An excess of glucocorticoids is also known to exert negative effects on
cerebral plasticity. In the present study, we assessed the effects of an
unbalanced diet on circulating and central markers of inflammation and
glucocorticoid activity, as well as their reversal by dietary cinnamon (CN)
supplementation. A group of male Wistar rats were subjected to an immune
challenge with acute lipopolysaccharide under a HF/HFr or a standard diet.
Another group of Wistar rats were fed either a HF/HFr or a control diet for 12
weeks, with or without CN supplementation, and with or without restraint stress
(Str) application before being killed. We evaluated the effects of such regimens
on inflammation parameters in the periphery and brain and on the expression of
actors of brain plasticity. To assess hypothalamic-pituitary-adrenocortical axis
activity, we measured the plasma concentrations of corticosterone and the
expression of central corticotrophin-releasing hormone, mineralocorticoid
receptor, glucocorticoid receptor and 11β-hydroxysteroid dehydrogenase. We found
that the HF/HFr diet induced the expression of cytokines in the brain, but only
after an immune challenge. Furthermore, we observed the negative effects of Str
on the plasma concentrations of corticosterone and neuroplasticity markers in
rats fed the control diet but not in those fed the HF/HFr diet. Additionally, we
found that CN supplementation exerted beneficial effects under the control diet,
but that its effects were blunted or even reversed under the HF/HFr diet. CN
supplementation could be beneficial under a standard diet. [corrected].
PMID: 24252462 [Indexed for MEDLINE]