Education, occupation, leisure activities, and brain reserve: a population-based study.
Neurobiology of Aging. 2012-02-01; 33(2): 423.e15-423.e25
DOI: 10.1016/j.neurobiolaging.2010.09.023
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1. Neurobiol Aging. 2012 Feb;33(2):423.e15-25. doi:
10.1016/j.neurobiolaging.2010.09.023. Epub 2010 Nov 12.
Education, occupation, leisure activities, and brain reserve: a population-based
study.
Foubert-Samier A(1), Catheline G, Amieva H, Dilharreguy B, Helmer C, Allard M,
Dartigues JF.
Author information:
(1)CMRR d’Aquitaine, CHU Bordeaux, Bordeaux, France.
The influence of education, occupation, and leisure activities on the passive and
active components of reserve capacity remains unclear. We used the voxel-based
morphometry (VBM) technique in a population-based sample of 331 nondemented
people in order to investigate the relationship between these factors and the
cerebral volume (a marker of brain reserve). The results showed a positive and
significant association between education, occupation, and leisure activities and
the cognitive performances on Isaac’s set test. Among these factors, only
education was significantly associated with a cerebral volume including gray and
white matter (p = 0.01). In voxel-based morphometry analyses, the difference in
gray matter volume was located in the temporoparietal lobes and in the
orbitofrontal lobes bilaterally (a p-value corrected