Education, occupation, leisure activities, and brain reserve: a population-based study.
Neurobiology of Aging. 2012-02-01; 33(2): 423.e15-423.e25
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1. Neurobiol Aging. 2012 Feb;33(2):423.e15-25. doi:
10.1016/j.neurobiolaging.2010.09.023. Epub 2010 Nov 12.
Education, occupation, leisure activities, and brain reserve: a population-based
Foubert-Samier A(1), Catheline G, Amieva H, Dilharreguy B, Helmer C, Allard M,
(1)CMRR d’Aquitaine, CHU Bordeaux, Bordeaux, France.
The influence of education, occupation, and leisure activities on the passive and
active components of reserve capacity remains unclear. We used the voxel-based
morphometry (VBM) technique in a population-based sample of 331 nondemented
people in order to investigate the relationship between these factors and the
cerebral volume (a marker of brain reserve). The results showed a positive and
significant association between education, occupation, and leisure activities and
the cognitive performances on Isaac’s set test. Among these factors, only
education was significantly associated with a cerebral volume including gray and
white matter (p = 0.01). In voxel-based morphometry analyses, the difference in
gray matter volume was located in the temporoparietal lobes and in the
orbitofrontal lobes bilaterally (a p-value corrected