Early and very early-onset schizophrenia compared with adult-onset schizophrenia: French FACE-SZ database
Brain Behav. 2020-01-07; 10(2):
DOI: 10.1002/brb3.1495
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1. Brain Behav. 2020 Feb;10(2):e01495. doi: 10.1002/brb3.1495. Epub 2020 Jan 7.
Early and very early-onset schizophrenia compared with adult-onset
schizophrenia: French FACE-SZ database.
Coulon N(1)(2)(3), Godin O(1)(2), Bulzacka E(1)(2), Dubertret C(1)(3), Mallet
J(1)(3), Fond G(1)(4), Brunel L(1)(2), Andrianarisoa M(1)(2), Anderson G(5),
Chereau I(1)(6), Denizot H(1)(6), Rey R(1)(7), Dorey JM(1)(7), Lançon C(1)(8),
Faget C(1)(8), Roux P(1)(9), Passerieux C(1)(9), Dubreucq J(1)(10), Leignier
S(1)(10), Capdevielle D(1)(11), André M(1)(11), Aouizerate B(1)(12), Misdrahi
D(1)(12), Berna F(1)(13), Vidailhet P(1)(13), Leboyer M(1)(2), Schürhoff
F(1)(2).
Author information:
(1)Fondation FondaMental, Créteil, France.
(2)INSERM U955, Translational Psychiatry laboratory, AP-HP, DHU Pe-PSY, Centre
Expert Schizophrénie, Pôle de Psychiatrie et d’Addictologie des Hôpitaux
Universitaires Henri Mondor, Université Paris Est Créteil, Créteil, France.
(3)INSERM U894, AP-HP, Department of Psychiatry, Louis Mourier Hospital, Paris
Diderot University, Sorbonne Paris Cité, Faculté de médecine, Colombes, France.
(4)EA 3279 : CEReSS -Centre d’Etude et de Recherche sur les Services de Santé et
la Qualité de vie, Aix-Marseille Univ, Faculté de Médecine, Marseille, France.
(5)CRC Scotland & London, Eccleston Square, London, UK.
(6)Clermont-Ferrand University Hospital, EA 7280 Auvergne University, BP 69,
Clermont-Ferrand, France.
(7)INSERM U1028, CNRS UMR 5292, Centre de Recherche en Neurosciences de Lyon,
Equipe PSYR2, Centre Hospitalier Le Vinatier, Pole Est, Claude Bernard Lyon 1
University, Bron Cedex, France.
(8)Department of Psychiatry (AP-HM), Sainte-Marguerite University Hospital,
Marseille, France.
(9)Department of Adult Psychiatry, Versailles Hospital, Le Chesnay, France.
(10)Psychosocial Rehabilitation Reference Center, Alpes Isère Hospital,
Grenoble, France.
(11)INSERM 1061, University Department of Adult Psychiatry, La Colombiere
Hospital, CHU Montpellier, University of Montpellier 1, Montpellier, France.
(12)Department of Adult Psychiatry, Charles Perrens Hospital, University of
Bordeaux, Bordeaux, France.
(13)INSERM U1114, Strasbourg University Hospital, University of Strasbourg,
Federation of Translational Psychiatry, Strasbourg, France.
OBJECTIVE: To compare the clinical symptomatology in patients with Early-Onset
Schizophrenia (EOS, N = 176), especially the subgroup Very Early Onset
Schizophrenia (VEOS) and Adult Onset Schizophrenia (AOS, N = 551).
METHOD: In a large French multicentric sample, 727 stable schizophrenia
patients, classified by age at onset of the disorder, were assessed using
standardized and extensive clinical and neuropsychological batteries: AOS with
onset ≥ 18 years and EOS with onset