Dynamics of surface neurotransmitter receptors and transporters in glial cells: Single molecule insights
Cell Calcium. 2017-11-01; 67: 46-52
DOI: 10.1016/j.ceca.2017.08.009
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1. Cell Calcium. 2017 Nov;67:46-52. doi: 10.1016/j.ceca.2017.08.009. Epub 2017 Aug
25.
Dynamics of surface neurotransmitter receptors and transporters in glial cells:
Single molecule insights.
Ciappelloni S(1), Murphy-Royal C(1), Dupuis JP(2), Oliet SHR(2), Groc L(3).
Author information:
(1)Interdisciplinary Institute for Neuroscience, CNRS UMR, 5297, Bordeaux,
France; University of Bordeaux, Bordeaux, France; Neurocentre Magendie, Inserm
U1215, Bordeaux, France.
(2)University of Bordeaux, Bordeaux, France; Neurocentre Magendie, Inserm U1215,
Bordeaux, France.
(3)Interdisciplinary Institute for Neuroscience, CNRS UMR, 5297, Bordeaux,
France; University of Bordeaux, Bordeaux, France. Electronic address:
.
The surface dynamics of neurotransmitter receptors and transporters, as well as
ion channels, has been well-documented in neurons, revealing complex molecular
behaviour and key physiological functions. However, our understanding of the
membrane trafficking and dynamics of the signalling molecules located at the
plasma membrane of glial cells is still in its infancy. Yet, recent breakthroughs
in the field of glial cells have been obtained using combination of
superresolution microscopy, single molecule imaging, and electrophysiological
recordings. Here, we review our current knowledge on the surface dynamics of
neurotransmitter receptors, transporters and ion channels, in glial cells. It has
emerged that the brain cell network activity, synaptic activity, and calcium
signalling, regulate the surface distribution and dynamics of these molecules.
Remarkably, the dynamics of a given neurotransmitter receptor/transporter at the
plasma membrane of a glial cell or neuron is unique, revealing the existence of
cell-type specific regulatory pathways. Thus, investigating the dynamics of
signalling proteins at the surface of glial cells will likely shed new light on
our understanding of glial cell physiology and pathology.
Copyright © 2017 Elsevier Ltd. All rights reserved.
DOI: 10.1016/j.ceca.2017.08.009
PMID: 29029790 [Indexed for MEDLINE]