Dynamics, nanoscale organization, and function of synaptic adhesion molecules

Ingrid Chamma, Olivier Thoumine
Molecular and Cellular Neuroscience. 2018-09-01; 91: 95-107
DOI: 10.1016/j.mcn.2018.04.007

PubMed
Lire sur PubMed



1. Mol Cell Neurosci. 2018 Sep;91:95-107. doi: 10.1016/j.mcn.2018.04.007. Epub 2018
Apr 17.

Dynamics, nanoscale organization, and function of synaptic adhesion molecules.

Chamma I(1), Thoumine O(2).

Author information:
(1)Interdisciplinary Institute for Neuroscience, UMR 5297, Centre National de la
Recherche Scientifique, 33077 Bordeaux, France; Interdisciplinary Institute for
Neuroscience, University of Bordeaux, 33077 Bordeaux, France; Institut National
de la Santé Et de la Recherche Médicale, France.
(2)Interdisciplinary Institute for Neuroscience, UMR 5297, Centre National de la
Recherche Scientifique, 33077 Bordeaux, France; Interdisciplinary Institute for
Neuroscience, University of Bordeaux, 33077 Bordeaux, France. Electronic address:
.

Synaptic adhesion molecules not only provide a physical link between pre- and
post-synaptic membranes, but also contribute to synaptic differentiation and
plasticity by organizing functional elements, in particular neurotransmitter
receptors. The wealth of existing adhesive protein families including many
isoforms and splice variants, calls for systematic identification of the levels
and exchange rates of each of those protein members at specific synapse types.
Complementary to electron microscopy to identify individual synaptic contacts and
biochemistry to reveal protein-protein interactions, recent super-resolution
light microscopy methods combined with appropriate fluorescent labeling provide a
way to measure the dynamics and sub-micron organization of selective molecular
components, and their inter-relations at the synapse. In this review, we
summarize current knowledge on the dynamics, nanoscale localization, and function
of key synaptic adhesion complexes.

Copyright © 2018 Elsevier Inc. All rights reserved.

DOI: 10.1016/j.mcn.2018.04.007
PMID: 29673914


Auteurs Bordeaux Neurocampus