Duration- and environment-dependent effects of repeated voluntary exercise on anxiety and cued fear in mice.
Behavioural Brain Research. 2015-04-01; 282: 1-5
DOI: 10.1016/j.bbr.2014.12.042
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1. Behav Brain Res. 2015 Apr 1;282:1-5. doi: 10.1016/j.bbr.2014.12.042. Epub 2014
Dec 26.
Duration- and environment-dependent effects of repeated voluntary exercise on
anxiety and cued fear in mice.
Dubreucq S(1), Marsicano G(1), Chaouloff F(2).
Author information:
(1)Endocannabinoids & NeuroAdaptation, NeuroCentre INSERM U862, 33077 Bordeaux,
France; University of Bordeaux, 33077 Bordeaux, France.
(2)Endocannabinoids & NeuroAdaptation, NeuroCentre INSERM U862, 33077 Bordeaux,
France; University of Bordeaux, 33077 Bordeaux, France. Electronic address:
.
Several studies have indicated that animal models of exercise, such as voluntary
wheel running, might be endowed with anxiolytic properties. Using the light/dark
test of unconditioned anxiety, we have reported that one confounding factor in
the estimation of wheel running impacts on anxiety might be the housing condition
of the sedentary controls. The present mouse study analyzed whether the
aforementioned observation in the light/dark test (i) could be repeated in the
elevated plus-maze and social interaction tests of unconditioned anxiety, (ii)
extended to conditioned anxiety, as assessed during cued fear recall tests, and
(iii) required unlimited daily access to the running wheel. Housing with a locked
wheel or with a free wheel that allowed limited or unlimited running activity
triggered anxiolysis in the light/dark test, but not in the elevated plus-maze
test, compared to standard housing. In the social interaction test, the duration,
but not the number, of social contacts was increased in mice provided unlimited
(but not limited) access to a wheel, compared to standard housing or housing with
a locked wheel. Lastly, freezing responses to a cue during fear recall tests
indicated that the reduction in freezing observed in mice provided limited or
unlimited access to the wheels was fully accounted for by housing with a wheel.
Besides confirming that the housing condition of the sedentary controls might
bias the estimation of the effects of wheel running on anxiety, this study
further shows that this estimation is dependent on the test used to assess
anxiety.
Copyright © 2014 Elsevier B.V. All rights reserved.
DOI: 10.1016/j.bbr.2014.12.042
PMID: 25546723 [Indexed for MEDLINE]