Dual effects of serotonin on a voltage-gated conductance in lymphocytes
Proceedings of the National Academy of Sciences. 1988-06-01; 85(12): 4557-4561
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1. Proc Natl Acad Sci U S A. 1988 Jun;85(12):4557-61.
Dual effects of serotonin on a voltage-gated conductance in lymphocytes.
Choquet D(1), Korn H.
(1)Institut National de la Santé et de la Recherche Médicale U261, Département
des Biotechnologies, Institut Pasteur, Paris, France.
The effects of serotonin (5-HT), a well-known immunomodulator and
neurotransmitter, on the ionic permeability of a pre-B lymphocyte cell line was
investigated with the whole-cell patch-clamp technique. We found that
physiological doses of this biogenic amine regulate a voltage-gated potassium
channel by activating different subsets of receptors. More specifically, 5-HT
induces in the recorded cells (i) increase in the maximum potassium conductance,
which is due to activation of 5-HT1-like receptors, and (ii) acceleration of the
inactivation process that is under the control of 5-HT3 receptors and,
accordingly, is mimicked by the 5-HT3 agonist, 2-methyl-5-HT; involvement of
those two distinct categories of receptors was demonstrated by using specific
antagonists that block predominantly one or the other of these two actions. These
two results show that hormones can affect lymphocyte physiology through
modulation of their ionic conductances in a way that might help explain some of
the diverse effects of 5-HT on neuronal cells.
PMID: 3260036 [Indexed for MEDLINE]