Dopamine Is Differentially Encoded by D2 Receptors in Striatal Subregions

Michel Engeln, Megan E. Fox, Mary Kay Lobo
Neuron. 2018-05-01; 98(3): 459-461
DOI: 10.1016/j.neuron.2018.04.016

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Engeln M(1), Fox ME(1), Lobo MK(2).

Author information:
(1)Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD, USA.
(2)Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD, USA. Electronic address: .

Comment on
Neuron. 2018 May 2;98(3):575-587.e4.

Striatal dopamine signaling is differentially regulated along the dorso-ventral
axis, but how these differences are encoded by dopamine receptors is unknown. In
this issue of Neuron, Marcott et al. (2018) show that dopamine activates D2
receptors in regionally distinct ways and dissect the underlying mechanisms
behind striatal D2 heterogeneity.