Distributions of transmitter receptors in the macaque cingulate cortex
NeuroImage. 2005-03-01; 25(1): 219-229
DOI: 10.1016/j.neuroimage.2004.10.040
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1. Neuroimage. 2005 Mar;25(1):219-29. Epub 2005 Jan 4.
Distributions of transmitter receptors in the macaque cingulate cortex.
Bozkurt A(1), Zilles K, Schleicher A, Kamper L, Arigita ES, Uylings HB, Kötter R.
Author information:
(1)C. and O. Vogt Brain Research Institute, Heinrich Heine University, D-40225
Düsseldorf, Germany.
The primate cingulate cortex is structurally and functionally complex. Although
no studies have investigated the regional densities of multiple neurotransmitter
receptor systems, such information would be useful for assessing its functions
and disease vulnerabilities. We quantified nine different receptors in five
transmitter systems by in vitro autoradiographic mapping of the cingulate cortex
of macaque monkeys with the aim to link cytoarchitectonic regions and functional
specialization. Receptor mapping substantiated the subdivision of the cingulate
cortex into anterior versus posterior regions. In anterior cingulate cortex (ACC)
AMPA glutamatergic receptors and GABA(A) inhibitory receptors were present in
significantly higher concentrations than the modulatory alpha-adrenergic and
muscarinic receptors. These differences were absent in the posterior cingulate
cortex (PCC). By contrast, NMDA receptor densities were significantly higher than
AMPA receptor densities in PCC, but not in ACC. The midcingulate area 24′ shared
more features with ACC than PCC. This area was characterized by the highest
ratios of NMDA receptors to alpha-adrenergic, muscarinic and 5-HT2 receptors
among all cingulate regions. Compared to rostrocaudal divisions, the differences
between dorsoventral subdivisions a-c were small in all regions of cingulate
cortex, and only muscarinic and alpha-adrenergic receptor densities followed the
degree of cytoarchitectonic differentiation. We conclude that multiple receptor
mapping reveals a highly differentiated classification of cingulate cortex with a
characteristic predominance of fast ionotropic excitatory and inhibitory
receptors in ACC, but a strong and varied complement of NMDA and metabotropic
receptors in PCC.
DOI: 10.1016/j.neuroimage.2004.10.040
PMID: 15734357 [Indexed for MEDLINE]