Distinctive alterations of the cingulum bundle during aging and Alzheimer’s disease.

Gwénaëlle Catheline, Olivier Periot, Marion Amirault, Marc Braun, Jean-François Dartigues, Sophie Auriacombe, Michèle Allard
Neurobiology of Aging. 2010-09-01; 31(9): 1582-1592
DOI: 10.1016/j.neurobiolaging.2008.08.012

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1. Neurobiol Aging. 2010 Sep;31(9):1582-92. doi:
10.1016/j.neurobiolaging.2008.08.012. Epub 2008 Oct 1.

Distinctive alterations of the cingulum bundle during aging and Alzheimer’s

Catheline G(1), Periot O, Amirault M, Braun M, Dartigues JF, Auriacombe S, Allard

Author information:
(1)IMF, UMR-CNRS 5231, Université Victor Segalen Bordeaux 2, Bordeaux, France.

Brain imaging studies have revealed frontal disruption during aging and
parieto-temporal disruption during Alzheimer’s disease (AD). The present study
aims at developing a specific method based on precise anatomical landmarks for
assessing the integrity all along the course of the cingulum bundle, so as to
determine if it presents the classical aging and AD dissociation. Five regions of
interest (ROIs) were placed on fractional anisotropy (FA) maps all along the
cingulum in 15 young (Gyoung), 15 70-year-old (Gold), and 15 AD subjects (Galz).
An age-related decrease of FA occurred in the anterior part of the bundle.
Moreover, a specific alteration of the supero-posterior region of the cingulum
during AD was observed since mean FA values as well as mean number of fibers were
significantly decreased in Galz compared to Gold and Gyoung. This multiple ROIs
placement allows for revealing distinctive alterations of the cingulum bundle
during aging and AD, which could constitute the anatomical basis for the
distinctive functional disconnection recently described in the literature using
functional connectivity at rest.

Copyright 2008 Elsevier Inc. All rights reserved.

DOI: 10.1016/j.neurobiolaging.2008.08.012
PMID: 18829135 [Indexed for MEDLINE]

Auteurs Bordeaux Neurocampus