Disrupting D1-NMDA or D2-NMDA receptor heteromerization prevents cocaine’s rewarding effects but preserves natural reward processing.

Andry Andrianarivelo, Estefani Saint-Jour, Paula Pousinha, Sebastian P. Fernandez, Anna Petitbon, Veronique De Smedt-Peyrusse, Nicolas Heck, Vanesa Ortiz, Marie-Charlotte Allichon, Vincent Kappès, Sandrine Betuing, Roman Walle, Ying Zhu, Charlène Joséphine, Alexis-Pierre Bemelmans, Gustavo Turecki, Naguib Mechawar, Jonathan A. Javitch, Jocelyne Caboche, Pierre Trifilieff, Jacques Barik, Peter Vanhoutte
Sci. Adv.. 2021-10-22; 7(43):
DOI: 10.1126/sciadv.abg5970

PubMed
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D2R-NMDAR receptor heteromers are potential therapeutic targets in drug addiction.

Auteurs Bordeaux Neurocampus