Differential role of insular cortex muscarinic and NMDA receptors in one-trial appetitive taste learning

Shauna L. Parkes, Vanesa De la Cruz, Federico Bermúdez-Rattoni, Etienne Coutureau, Guillaume Ferreira
Neurobiology of Learning and Memory. 2014-12-01; 116: 112-116
DOI: 10.1016/j.nlm.2014.09.008

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1. Neurobiol Learn Mem. 2014 Dec;116:112-6. doi: 10.1016/j.nlm.2014.09.008. Epub
2014 Oct 6.

Differential role of insular cortex muscarinic and NMDA receptors in one-trial
appetitive taste learning.

Parkes SL(1), De la Cruz V(2), Bermúdez-Rattoni F(2), Coutureau E(3), Ferreira
G(4).

Author information:
(1)INRA, Nutrition and Integrative Neurobiology, UMR 1286, 33076 Bordeaux,
France; CNRS, Institut de Neurosciences Cognitives et Intégratives d’Aquitaine,
UMR 5287, 33076 Bordeaux, France; Université de Bordeaux, 33076 Bordeaux, France.
(2)Departamento de Neurociencias, Instituto de Fisiología Celular, Universidad
Nacional Autónoma de México, 04510 México DF, Mexico.
(3)CNRS, Institut de Neurosciences Cognitives et Intégratives d’Aquitaine, UMR
5287, 33076 Bordeaux, France; Université de Bordeaux, 33076 Bordeaux, France.
(4)INRA, Nutrition and Integrative Neurobiology, UMR 1286, 33076 Bordeaux,
France; Université de Bordeaux, 33076 Bordeaux, France. Electronic address:
.

Our current understanding of the neurobiology of taste learning and memory has
been greatly facilitated by the use of a reliable behavioural model, conditioned
taste aversion (CTA). This model has revealed that the insular cortex (IC),
specifically muscarinic and N-methyl-d-aspartate (NMDA) receptor activation in
the IC, is critical for the formation of aversive taste memories. In contrast,
current models of appetitive taste learning are less adequate, relying on the use
of neophobic tastes (attenuation of neophobia) or on the integration of
appetitive and aversive taste memories (latent inhibition of CTA). While these
models have implicated IC muscarinic receptors, the involvement of NMDA receptors
in the IC remains unclear. Here, we examined the role of both muscarinic and NMDA
receptors in appetitive taste learning using a simple paradigm that is
independent of neophobic and aversive components. First, we demonstrated that a
single exposure to a novel taste, saccharin 0.1%, is sufficient to promote an
appetitive taste memory as revealed by an increase in saccharin consumption
during the second presentation. This increase was blocked by bilateral infusion
in the IC of the muscarinic receptor antagonist, scopolamine. In contrast,
infusion of the NMDA receptor antagonist, AP5, did not block appetitive taste
learning but did abolish CTA. Therefore, common and distinct molecular substrates
within the IC mediate appetitive versus aversive learning about the same taste.

Copyright © 2014 Elsevier Inc. All rights reserved.

DOI: 10.1016/j.nlm.2014.09.008
PMID: 25300672 [Indexed for MEDLINE]


Auteurs Bordeaux Neurocampus