Differential annualized rates of hippocampal subfields atrophy in aging and future Alzheimer’s clinical syndrome.
Neurobiology of Aging. 2020-06-01; 90: 75-83
DOI: 10.1016/j.neurobiolaging.2020.01.011
Lire sur PubMed
1. Neurobiol Aging. 2020 Jun;90:75-83. doi: 10.1016/j.neurobiolaging.2020.01.011.
Epub 2020 Feb 1.
Differential annualized rates of hippocampal subfields atrophy in aging and
future Alzheimer’s clinical syndrome.
Nadal L(1), Coupé P(2), Helmer C(3), Manjon JV(4), Amieva H(3), Tison F(1),
Dartigues JF(5), Catheline G(6), Planche V(7).
Author information:
(1)Univ. Bordeaux, CNRS, Institut des Maladies Neurodégénératives, Bordeaux,
France; Centre Mémoire de Ressources et de Recherches, Pôle de Neurosciences
Cliniques, CHU de Bordeaux, Bordeaux, France.
(2)Univ. Bordeaux, CNRS, Laboratoire Bordelais de Recherche en Informatique,
Talence, France.
(3)Univ. Bordeaux, Inserm, Bordeaux Population Health Research Center, Bordeaux,
France.
(4)Instituto de Aplicaciones de las Tecnologías de la Información y de las
Comunicaciones Avanzadas (ITACA), Universitat Politècnica de València, Valencia,
Spain.
(5)Centre Mémoire de Ressources et de Recherches, Pôle de Neurosciences
Cliniques, CHU de Bordeaux, Bordeaux, France; Univ. Bordeaux, Inserm, Bordeaux
Population Health Research Center, Bordeaux, France.
(6)EPHE, PSL, Bordeaux, France; Univ. Bordeaux, CNRS, Institut de Neurosciences
cognitives et intégratives d’Aquitaine, Bordeaux, France.
(7)Univ. Bordeaux, CNRS, Institut des Maladies Neurodégénératives, Bordeaux,
France; Centre Mémoire de Ressources et de Recherches, Pôle de Neurosciences
Cliniques, CHU de Bordeaux, Bordeaux, France. Electronic address:
.
Several studies have investigated the differential vulnerability of hippocampal
subfields during aging and Alzheimer’s disease (AD). Results were often
contradictory, mainly because these works were based on concatenations of
cross-sectional measures in cohorts with different ages or stages of AD, in the
absence of a longitudinal design. Here, we investigated 327 participants from a
population-based cohort of nondemented older adults with a 14-year clinical
follow-up. MRI at baseline and 4 years later were assessed to measure the
annualized rates of hippocampal subfields atrophy in each participant using an
automatic segmentation pipeline with subsequent quality control. On the one hand,
CA4 dentate gyrus was significantly more affected than the other subfields in the
whole population (CA1-3: -0.68%/year; subiculum: -0.99%/year; and
CA4-DG: -1.39%/year; p < 0.0001). On the other hand, the annualized rate of CA1-3
atrophy was associated with an increased risk of developing Alzheimer's clinical
syndrome over time, independently of age, gender, educational level, and ApoE4
genotype (HR = 2.0; CI 95% 1.4-3.0). These results illustrate the natural history
of hippocampal subfields atrophy during aging and AD by showing that the dentate
gyrus is the most vulnerable subfield to the effects of aging while the
cornu-ammonis is the primary target of AD pathophysiological processes, years
before symptom onset.
Copyright © 2020 Elsevier Inc. All rights reserved.
DOI: 10.1016/j.neurobiolaging.2020.01.011
PMID: 32107063 [Indexed for MEDLINE]