Different neuroendocrine cell types in the pars intercerebralis of Periplaneta americana produce their own specific IGF-related peptides

Jan A. Veenstra
General and Comparative Endocrinology. 2023-05-01; 335: 114233
DOI: 10.1016/j.ygcen.2023.114233

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Veenstra JA(1).

Author information:
(1)INCIA UMR 5287 CNRS, Université de Bordeaux, allée Geoffroy St Hillaire, CS
50023, 33 615 Pessac Cedex, France. Electronic address:

Of the nine genes of the American cockroach, Periplaneta americana, coding for
peptides related to insulin and insulin-like growth factor, seven show
significant expression in the central nervous system as demonstrated by the
polymerase chain reaction on reverse transcribed RNA. In situ hybridisation
shows that five of those are expressed by cells in the pars intercerebralis.
Antisera raised to the predicted peptides show that these cells are
neuroendocrine in nature and project to the corpora cardiaca. Interestingly,
there are at least three cell types that each express different genes. This
contrasts with Drosophila where a single cell type expresses a number of genes
expressing several such peptides. Whereas in Drosophila the neuroendocrine cells
producing insulin-like peptides also express sulfakinins, the arthropod
orthologs of gastrin and cholecystokinin, in Periplaneta the sulfakinins are
produced by different cells. Other neuropeptides known to be produced by the
pars intercerebralis in Periplaneta and other insect species, such as the
CRF-like diuretic hormone, neuroparsin, leucokinin or myosuppressin, neither
colocalize with an insulin-related peptide. The separate cellular localization
of these peptides and the existence of multiple insulin receptors in this
species implies a more complex regulation by insulin and IGF-related peptides in
cockroaches than in the fruit fly.

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