Differences in ultrastructural localization of dopaminergic D1 receptors between dorsal striatum and nucleus accumbens in the rat.
Neuroscience Letters. 2007-06-01; 419(3): 273-277
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1. Neurosci Lett. 2007 Jun 4;419(3):273-7. Epub 2007 Apr 21.
Differences in ultrastructural localization of dopaminergic D1 receptors between
dorsal striatum and nucleus accumbens in the rat.
Dumartin B(1), Doudnikoff E, Gonon F, Bloch B.
(1)Université Bordeaux 2, CNRS UMR 5227, Bordeaux, France.
Dopaminergic receptors of the D1 type are highly expressed in the dorsal striatum
and nucleus accumbens. In the dorsal striatum, they are rarely observed on
presynaptic terminals. However, their subcellular localization in the nucleus
accumbens core and shell had not been compared to that of dorsal striatum. Here
we investigated the subcellular localization of D1 receptors in these three brain
regions using immunogold labeling and electron microscopy. We showed that, among
all presynaptic terminals forming asymmetric contact with dendritic processes,
the percentage of D1R immunoreactive terminals was low in the dorsal striatum
(8.2%), but reached in the nucleus accumbens core and shell 25.5 and 29%,
respectively. These observations are consistent with electrophysiological
studies, which showed that D1 stimulation inhibits the response of target neurons
to glutamatergic input via presynaptic mechanisms in the nucleus accumbens but
not in the dorsal striatum.
PMID: 17498877 [Indexed for MEDLINE]