Differences in meibomian fatty acid composition in patients with meibomian gland dysfunction and aqueous-deficient dry eye

C Joffre, M Souchier, S Gregoire, S Viau, L Bretillon, N Acar, A M Bron, C Creuzot-Garcher
British Journal of Ophthalmology. 2007-12-21; 92(1): 116-119
DOI: 10.1136/bjo.2007.126144

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1. Br J Ophthalmol. 2008 Jan;92(1):116-9.

Differences in meibomian fatty acid composition in patients with meibomian gland
dysfunction and aqueous-deficient dry eye.

Joffre C(1), Souchier M, Grégoire S, Viau S, Bretillon L, Acar N, Bron AM,
Creuzot-Garcher C.

Author information:
(1)Eye and Nutrition Research Group, National Institute for Research on Agronomy,
Dijon, France.

AIMS: To evaluate the differences in meibomian fatty acid composition in healthy
subjects and in patients suffering from meibomian gland dysfunction or
aqueous-deficient dry eye.
METHODS: We collected meibomian oil using a sterile Schirmer paper in healthy
individuals (n = 20), dry eye patients (aqueous-deficient) (n = 32) and meibomian
gland dysfunction (MGD) patients (n = 25) after gentle massage of the lid margin.
Meibomian fatty acids were directly transmethylated and analysed using gas
chromatography (GC) and GC mass spectrometry.
RESULTS: Meibomian fatty acids were similar in healthy individuals and in dry eye
patients but were different in MGD patients, who showed significantly higher
levels of branched-chain fatty acids (29.8% vs 20.2%) (p

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