Dietary polyphenol supplementation prevents alterations of spatial navigation in middle-aged mice

Julien Bensalem, Laure Servant, Serge Alfos, David Gaudout, Sophie Layé, Pauline Lafenetre, Véronique Pallet
Front. Behav. Neurosci.. 2016-02-09; 10:
DOI: 10.3389/fnbeh.2016.00009

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1. Front Behav Neurosci. 2016 Feb 9;10:9. doi: 10.3389/fnbeh.2016.00009. eCollection
2016.

Dietary Polyphenol Supplementation Prevents Alterations of Spatial Navigation in
Middle-Aged Mice.

Bensalem J(1), Servant L(2), Alfos S(3), Gaudout D(4), Layé S(2), Pallet V(3),
Lafenetre P(3).

Author information:
(1)Nutrition et Neurobiologie Intégrée, Université de Bordeaux, UMR 1286Bordeaux,
France; INRA, Nutrition et Neurobiologie Intégrée, UMR 1286Bordeaux, France;
Activ’InsideLibourne, France.
(2)Nutrition et Neurobiologie Intégrée, Université de Bordeaux, UMR 1286Bordeaux,
France; INRA, Nutrition et Neurobiologie Intégrée, UMR 1286Bordeaux, France.
(3)Nutrition et Neurobiologie Intégrée, Université de Bordeaux, UMR 1286Bordeaux,
France; INRA, Nutrition et Neurobiologie Intégrée, UMR 1286Bordeaux, France;
Nutrition et Neurobiologie Intégrée, Bordeaux INP, UMR 1286Bordeaux, France.
(4)Activ’Inside Libourne, France.

Spatial learning and memory deficits associated with hippocampal synaptic
plasticity impairments are commonly observed during aging. Besides, the
beneficial role of dietary polyphenols has been suggested as potential functional
food candidates to prevent this memory decline. Indeed, polyphenols could
potentiate the signaling pathways of synaptic plasticity underlying learning and
memory. In this study, spatial learning deficits of middle-aged mice were first
highlighted and characterized according to their navigation patterns in the
Morris water maze task. An eight-week polyphenol-enriched diet, containing a
polyphenol-rich extract from grape and blueberry (PEGB; from the Neurophenols
Consortium) with high contents of flavonoids, stilbenes and phenolic acids, was
then successful in reversing these age-induced effects. The use of spatial
strategies was indeed delayed with aging whereas a polyphenol supplementation
could promote the occurrence of spatial strategies. These behavioral results were
associated with neurobiological changes: while the expression of hippocampal
calmodulin kinase II (CaMKII) mRNA levels was reduced in middle-aged animals, the
polyphenol-enriched diet could rescue them. Besides, an increased expression of
nerve growth neurotrophic factor (NGF) mRNA levels was also observed in
supplemented adult and middle-aged mice. Thus these data suggest that
supplementation with polyphenols could be an efficient nutritional way to prevent
age-induced cognitive decline.

DOI: 10.3389/fnbeh.2016.00009
PMCID: PMC4746350
PMID: 26903826

Auteurs Bordeaux Neurocampus