Dichotomous activity and function of neurons with low- and high-frequency discharge in the external globus pallidus of non-human primates
Cell Reports. 2023-01-01; : 111898
DOI: 10.1016/j.celrep.2022.111898
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Katabi S(1), Adler A(2), Deffains M(3), Bergman H(4).
Author information:
(1)Department of Medical Neuroscience, Institute of Medical Research
Israel-Canada (IMRIC), The Hebrew University-Hadassah Medical School, 91120
Jerusalem, Israel. Electronic address: .
(2)Department of Medical Neuroscience, Institute of Medical Research
Israel-Canada (IMRIC), The Hebrew University-Hadassah Medical School, 91120
Jerusalem, Israel; The Edmond and Lily Safra Center for Brain Sciences, The
Hebrew University, Jerusalem 91904, Israel.
(3)University of Bordeaux, UMR 5293, IMN, 33000 Bordeaux, France; CNRS, UMR
5293, IMN, 33000 Bordeaux, France.
(4)Department of Medical Neuroscience, Institute of Medical Research
Israel-Canada (IMRIC), The Hebrew University-Hadassah Medical School, 91120
Jerusalem, Israel; The Edmond and Lily Safra Center for Brain Sciences, The
Hebrew University, Jerusalem 91904, Israel; Department of Neurosurgery, Hadassah
Medical Center, Jerusalem 91120, Israel.
To date, there is a consensus that there are at least two neuronal populations
in the non-human primate (NHP) external globus pallidus (GPe): low-frequency
discharge (LFD) and high-frequency discharge (HFD) neurons. Nevertheless, almost
all NHP physiological studies have neglected the functional importance of LFD
neurons. This study examined the discharge features of these two GPe neuronal
subpopulations recorded in four NHPs engaged in a classical conditioning task
with cues predicting reward, neutral and aversive outcomes. The results show
that LFD neurons tended to burst, encoded the salience of behavioral cues, and
exhibited correlated spiking activity. By contrast, the HFD neurons tended to
pause, encoded cue valence, and exhibited uncorrelated spiking activity.
Overall, these findings point to the dichotomic organization of the NHP GPe,
which is likely to be critical to the implementation of normal basal ganglia
functions and computations.
Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.