Diagnosing dementia in multiple system atrophy by applying Movement Disorder Society diagnostic criteria for Parkinson’s disease dementia
Parkinsonism & Related Disorders. 2015-10-01; 21(10): 1273-1277
DOI: 10.1016/j.parkreldis.2015.08.013
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1. Parkinsonism Relat Disord. 2015 Oct;21(10):1273-7. doi:
10.1016/j.parkreldis.2015.08.013. Epub 2015 Aug 14.
Diagnosing dementia in multiple system atrophy by applying Movement Disorder
Society diagnostic criteria for Parkinson’s disease dementia.
Auzou N(1), Dujardin K(2), Biundo R(3), Foubert-Samier A(4), Barth C(5), Duval
F(6), Tison F(4), Defebvre L(2), Antonini A(3), Meissner WG(7).
Author information:
(1)Service de Neurologie, CHU de Bordeaux, Bordeaux, France; Univ. de Bordeaux,
Laboratoire de Psychologie, Santé et Qualité de Vie, EA4139, Bordeaux, France.
(2)Service de Neurologie et Pathologies du Mouvement, CHRU de Lille, France;
Inserm U1171, Troubles cognitifs dégénératifs et vasculaires, Université de
Lille, Lille, France.
(3)Parkinson and Movement Disorders Unit, Fondazione Ospedale San Camillo,
Venice, Italy.
(4)Service de Neurologie, CHU de Bordeaux, Bordeaux, France; Centre de référence
atrophie multisystématisée, CHU de Bordeaux, Bordeaux, France; Univ. de Bordeaux,
Institut des Maladies Neurodégénératives, UMR 5293, Bordeaux, France; CNRS,
Institut des Maladies Neurodégénératives, UMR 5293, Bordeaux, France.
(5)Centre de référence atrophie multisystématisée, CHU de Bordeaux, Bordeaux,
France.
(6)Service de Neurologie, CHU de Bordeaux, Bordeaux, France.
(7)Service de Neurologie, CHU de Bordeaux, Bordeaux, France; Centre de référence
atrophie multisystématisée, CHU de Bordeaux, Bordeaux, France; Univ. de Bordeaux,
Institut des Maladies Neurodégénératives, UMR 5293, Bordeaux, France; CNRS,
Institut des Maladies Neurodégénératives, UMR 5293, Bordeaux, France. Electronic
address: .
INTRODUCTION: Dementia is an exclusion criterion in current consensus diagnostic
criteria, while growing evidence suggests the occurrence of cognitive dysfunction
and even dementia in multiple system atrophy (MSA) patients. The main goal of
this study was to determine if Movement Disorder Society (MDS) Parkinson’s
disease dementia (PDD) LEVEL-1 criteria are useful in screening for dementia in
MSA patients compared to full cognitive testing (LEVEL-2 criteria).
METHODS: In this retrospective study, MDS diagnostic criteria for PDD were
applied in 111 MSA patients from three centres. LEVEL-1 evaluation (short
screening test) was compared to LEVEL-2 examination (extensive neuropsychological
gold standard assessment). Sensitivity, specificity, positive and negative
predictive values were calculated for LEVEL-1 compared to LEVEL-2. Two Mini
Mental State Examination (MMSE) cut-off scores were evaluated (