Development and Patterning of the Cochlea: From Convergent Extension to Planar Polarity.
Cold Spring Harb Perspect Med. 2019-01-07; : a033266
DOI: 10.1101/cshperspect.a033266
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Cold Spring Harb Perspect Med. 2019 Jan 7. pii: a033266.
doi: 10.1101/cshperspect.a033266.
Development and Patterning of the Cochlea: From Convergent Extension to Planar Polarity.
Montcouquiol M(1)(2), Kelley MW(3).
Author information:
(1)INSERM, Neurocentre Magendie, U1215, F-33077 Bordeaux, France.
(2)University of Bordeaux, Neurocentre Magendie, U1215, F-33077 Bordeaux, France.
(3)Laboratory of Cochlear Development, National Institute on Deafness and Other
Communication Disorders, National Institutes of Health, Bethesda, Maryland 20892.
Within the mammalian cochlea, sensory hair cells and supporting cells are aligned
in curvilinear rows that extend along the length of the tonotopic axis. In
addition, all of the cells within the epithelium are uniformly polarized across
the orthogonal neural-abneural axis. Finally, each hair cell is intrinsically
polarized as revealed by the presence of an asymmetrically shaped and apically
localized stereociliary bundle. It has been known for some time that many of the
developmental processes that regulate these patterning events are mediated, to
some extent, by the core planar cell polarity (PCP) pathway. This article will
review more recent work demonstrating how components of the PCP pathway interact
with cytoskeletal motor proteins to regulate cochlear outgrowth. Finally, a
signaling pathway originally identified for its role in asymmetric cell divisions
has recently been shown to mediate several aspects of intrinsic hair cell
polarity, including kinocilia migration, bundle shape, and elongation.
Copyright © 2019 Cold Spring Harbor Laboratory Press; all rights reserved.
DOI: 10.1101/cshperspect.a033266
PMID: 30617059