Dentate Granule Neurons Generated During Perinatal Life Display Distinct Morphological Features Compared With Later-Born Neurons in the Mouse Hippocampus
Cerebral Cortex. 2018-09-12; :
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1. Cereb Cortex. 2018 Sep 12. doi: 10.1093/cercor/bhy224.
Dentate Granule Neurons Generated During Perinatal Life Display Distinct
Morphological Features Compared With Later-Born Neurons in the Mouse Hippocampus.
Kerloch T(1)(2), Clavreul S(1)(2), Goron A(1)(2), Abrous DN(1)(2), Pacary
(1)INSERM U1215, Neurocentre Magendie, Bordeaux, France.
(2)Université de Bordeaux, Bordeaux, France.
In nonhuman mammals and in particular in rodents, most granule neurons of the
dentate gyrus (DG) are generated during development and yet little is known about
their properties compared with adult-born neurons. Although it is generally
admitted that these populations are morphologically indistinguishable once
mature, a detailed analysis of developmentally born neurons is lacking. Here, we
used in vivo electroporation to label dentate granule cells (DGCs) generated in
mouse embryos (E14.5) or in neonates (P0) and followed their morphological
development up to 6 months after birth. By comparison with mature
retrovirus-labeled DGCs born at weaning (P21) or young adult (P84) stages, we
provide the evidence that perinatally born neurons, especially embryonically born
cells, are morphologically distinct from later-born neurons and are thus easily
distinguishable. In addition, our data indicate that semilunar and hilar GCs, 2
populations in ectopic location, are generated during the embryonic and the
neonatal periods, respectively. Thus, our findings provide new insights into the
development of the different populations of GCs in the DG and open new questions
regarding their function in the brain.