Deep brain stimulation mechanisms: beyond the concept of local functional inhibition
European Journal of Neuroscience. 2010-10-01; 32(7): 1080-1091
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1. Eur J Neurosci. 2010 Oct;32(7):1080-91. doi: 10.1111/j.1460-9568.2010.07413.x.
Deep brain stimulation mechanisms: beyond the concept of local functional
Deniau JM(1), Degos B, Bosch C, Maurice N.
(1)Institut National de la Santé et de la Recherche Médicale U.667, Dynamique et
Physiopathologie des Réseaux Neuronaux, Collège de France, 11 Place Marcelin
Berthelot, 75231 Paris Cedex 05 France.
Deep brain electrical stimulation has become a recognized therapy in the
treatment of a variety of motor disorders and has potentially promising
applications in a wide range of neurological diseases including neuropsychiatry.
Behavioural observation that electrical high-frequency stimulation of a given
brain area induces an effect similar to a lesion suggested a mechanism of
functional inhibition. In vitro and in vivo experiments as well as per operative
recordings in patients have revealed a variety of effects involving local changes
of neuronal excitability as well as widespread effects throughout the connected
network resulting from activation of axons, including antidromic activation. Here
we review current data regarding the local and network activity changes induced
by high-frequency stimulation of the subthalamic nucleus and discuss this in the
context of motor restoration in Parkinson’s disease. Stressing the important
functional consequences of axonal activation in deep brain stimulation
mechanisms, we highlight the importance of developing anatomical knowledge
concerning the fibre connections of the putative therapeutic targets.
© 2010 The Authors. European Journal of Neuroscience © 2010 Federation of
European Neuroscience Societies and Blackwell Publishing Ltd.
PMID: 21039947 [Indexed for MEDLINE]