Cytoplasmic expression of human telomerase catalytic protein (hTERT) in neutrophils: an immunoelectron microscopy study.
Ultrastructural Pathology. 2008-01-01; 32(5): 178-183
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1. Ultrastruct Pathol. 2008 Sep-Oct;32(5):178-83. doi: 10.1080/01913120802034504.
Cytoplasmic expression of human telomerase catalytic protein (hTERT) in
neutrophils: an immunoelectron microscopy study.
Lepreux S(1), Doudnikoff E, Aubert I, Bioulac-Sage P, Bloch B, Martin-Negrier ML.
(1)Laboratoire d’Histologie-Embryologie, UFR II, Universite Victor Segalen
Bordeaux, France. *protected email*
Human telomerase comprises a catalytic protein subunit (hTERT) and an RNA subunit
(hTR). Telomerase extends chromosome ends in compensation for the attrition of
the telomeres during replication. In this work, the authors explore the
expression of hTERT and hTR in neutrophils, respectively by immunochemistry
techniques and in situ hybridization. hTERT was strongly expressed in neutrophils
cytoplasm. The ultrastructural study showed that the gold particles were not
associated with specific organelles but scattered in the cytosol. hTR was not
expressed. hTERT is expressed in the cytoplasm of neutrophils, but its
roles-eventually extratelomeric effects-remain to be elucidated.
PMID: 18958789 [Indexed for MEDLINE]