Cytokines and psychopathology: lessons from interferon-alpha.
Biological Psychiatry. 2004-12-01; 56(11): 819-824
DOI: 10.1016/j.biopsych.2004.02.009
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1. Biol Psychiatry. 2004 Dec 1;56(11):819-24.
Cytokines and psychopathology: lessons from interferon-alpha.
Capuron L(1), Miller AH.
Author information:
(1)Department of Psychiatry and Behavioral Sciences, Emory University School of
Medicine, Atlanta, GA 30322, USA.
Interferon-alpha is a potent inducer of the cytokine network and is notorious for
causing behavioral alterations. Studies on interferon-alpha-treated patients
reveal at least two distinct syndromes: 1) a mood/cognitive syndrome that appears
late during interferon-alpha therapy is responsive to antidepressants and is
associated with activation of neuroendocrine pathways and altered serotonin
metabolism; and 2) a neurovegetative syndrome characterized by psychomotor
slowing, and fatigue that appears early during interferon-alpha treatment is
antidepressant nonresponsive and may be mediated by alterations in basal ganglia
dopamine metabolism. Findings from interferon-alpha may provide important clues
regarding the pathophysiology and treatment of cytokine-induced behavioral
changes in medically ill patients, while also potentially modeling the
development of neuropsychiatric symptoms in patients without medical disorders.
DOI: 10.1016/j.biopsych.2004.02.009
PMID: 15576057 [Indexed for MEDLINE]