Coordinated reset neuromodulation for Parkinson’s disease: Proof-of-concept study.

Ilya Adamchic, Christian Hauptmann, Utako Brigit Barnikol, Norbert Pawelczyk, Oleksandr Popovych, Thomas Theo Barnikol, Alexander Silchenko, Jens Volkmann, Günter Deuschl, Wassilios G Meissner, Mohammad Maarouf, Volker Sturm, Hans-Joachim Freund, Peter Alexander Tass
Mov Disord.. 2014-06-28; 29(13): 1679-1684
DOI: 10.1002/mds.25923

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1. Mov Disord. 2014 Nov;29(13):1679-84. doi: 10.1002/mds.25923. Epub 2014 Jun 28.

Coordinated reset neuromodulation for Parkinson’s disease: proof-of-concept

Adamchic I(1), Hauptmann C, Barnikol UB, Pawelczyk N, Popovych O, Barnikol TT,
Silchenko A, Volkmann J, Deuschl G, Meissner WG, Maarouf M, Sturm V, Freund HJ,
Tass PA.

Author information:
(1)Institute of Neuroscience and Medicine-Neuromodulation, Jülich Research
Center, Jülich, Germany.

BACKGROUND: The discovery of abnormal synchronization of neuronal activity in the
basal ganglia in Parkinson’s disease (PD) has prompted the development of novel
neuromodulation paradigms. Coordinated reset neuromodulation intends to
specifically counteract excessive synchronization and to induce cumulative
unlearning of pathological synaptic connectivity and neuronal synchrony.
METHODS: In this prospective case series, six PD patients were evaluated before
and after coordinated reset neuromodulation according to a standardized protocol
that included both electrophysiological recordings and clinical assessments.
RESULTS: Coordinated reset neuromodulation of the subthalamic nucleus (STN)
applied to six PD patients in an externalized setting during three stimulation
days induced a significant and cumulative reduction of beta band activity that
correlated with a significant improvement of motor function.
CONCLUSIONS: These results highlight the potential effects of coordinated reset
neuromodulation of the STN in PD patients and encourage further development of
this approach as an alternative to conventional high-frequency deep brain
stimulation in PD.

© 2014 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on
behalf of International Parkinson and Movement Disorder Society.

DOI: 10.1002/mds.25923
PMCID: PMC4282372
PMID: 24976001 [Indexed for MEDLINE]

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