Coordinated reset has sustained aftereffects in Parkinsonian monkeys.
Ann Neurol.. 2012-11-01; 72(5): 816-820
DOI: 10.1002/ana.23663
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1. Ann Neurol. 2012 Nov;72(5):816-20. doi: 10.1002/ana.23663.
Coordinated reset has sustained aftereffects in Parkinsonian monkeys.
Tass PA(1), Qin L, Hauptmann C, Dovero S, Bezard E, Boraud T, Meissner WG.
Author information:
(1)Institute for Medicine and Neurosciences, Research Center Jülich, Jülich,
Germany.
Coordinated reset neuromodulation consists of the application of consecutive
brief high-frequency pulse trains through the different contacts of the
stimulation electrode. In theoretical studies, by achieving unlearning of
abnormal connectivity between neurons, coordinated reset neuromodulation reduces
pathological synchronization, a hallmark feature of Parkinson’s disease
pathophysiology. Here we show that coordinated reset neuromodulation of the
subthalamic nucleus has both acute and sustained long-lasting aftereffects on
motor function in parkinsonian nonhuman primates. Long-lasting aftereffects were
not observed with classical deep brain stimulation. These observations encourage
further development of coordinated reset neuromodulation for treating motor
symptoms in Parkinson disease patients.
Copyright © 2012 American Neurological Association.
DOI: 10.1002/ana.23663
PMID: 23280797 [Indexed for MEDLINE]