Contusion Rodent Model of Traumatic Brain Injury: Controlled Cortical Impact
Methods in Molecular Biology. 2020-08-18; : 49-65
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Fournier ML(1), Clément T(1), Aussudre J(1), Plesnila N(2), Obenaus A(3)(4), Badaut J(5)(6).
(1)CNRS UMR5287, INCIA, University of Bordeaux, Bordeaux, France.
(2)Institute for Stroke and Dementia Research (ISD), University of Munich Medical Center, Munich, Germany.
(3)Department of Pediatrics, University of California, Irvine, Irvine, CA, USA.
(4)Department of Basic Sciences, Loma Linda University School of Medicine, Loma Linda, CA, USA.
(5)CNRS UMR5287, INCIA, University of Bordeaux, Bordeaux, France. .
(6)Department of Basic Sciences, Loma Linda University School of Medicine, Loma Linda, CA, USA. .
Traumatic brain injury (TBI) is a heterogeneous brain injury which represents one of the leading causes of mortality and disability worldwide. Rodent TBI models are helpful to examine the cellular and molecular mechanisms after injury. Controlled cortical impact (CCI) is one of the most commonly used TBI models in
rats and mice, based on its consistency of injury and ease of implementation. Here, we describe a CCI protocol to induce a moderate contusion to the somatosensory motor cortex. We provide additional protocols for monitoring animals after CCI induction.