Control of glutamate clearance and synaptic efficacy by glial coverage of neurons.

S. H. R. Oliet
Science. 2001-05-04; 292(5518): 923-926
DOI: 10.1126/science.1059162

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1. Science. 2001 May 4;292(5518):923-6.

Control of glutamate clearance and synaptic efficacy by glial coverage of
neurons.

Oliet SH(1), Piet R, Poulain DA.

Author information:
(1)INSERM U.378, Université Victor Segalen-Bordeaux 2, 33077 Bordeaux, France.

Comment in
Science. 2001 May 4;292(5518):872-3.

Analysis of excitatory synaptic transmission in the rat hypothalamic supraoptic
nucleus revealed that glutamate clearance and, as a consequence, glutamate
concentration and diffusion in the extracellular space, is associated with the
degree of astrocytic coverage of its neurons. Reduction in glutamate clearance,
whether induced pharmacologically or associated with a relative decrease of glial
coverage in the vicinity of synapses, affected transmitter release through
modulation of presynaptic metabotropic glutamate receptors. Astrocytic wrapping
of neurons, therefore, contributes to the regulation of synaptic efficacy in the
central nervous system.

DOI: 10.1126/science.1059162
PMID: 11340204 [Indexed for MEDLINE]

Auteurs Bordeaux Neurocampus