Computational insights into mRNA and protein dynamics underlying synaptic plasticity rules
Molecular and Cellular Neuroscience. 2023-06-01; 125: 103846
DOI: 10.1016/j.mcn.2023.103846
1. Mol Cell Neurosci. 2023 Jun;125:103846. doi: 10.1016/j.mcn.2023.103846. Epub
2023 Mar 22.
Computational insights into mRNA and protein dynamics underlying synaptic
plasticity rules.
Wagle S(1), Kraynyukova N(2), Hafner AS(3), Tchumatchenko T(4).
Author information:
(1)Institute for Physiological Chemistry, University Medical Center of the
Johannes Gutenberg-University Mainz, Anselm-Franz-von-Bentzel-Weg 3, 55128
Mainz, Germany.
(2)Institute of Experimental Epileptology and Cognition Research, University of
Bonn, Venusberg-Campus 1, 53127 Bonn, Germany.
(3)Donders Institute for Brain, Cognition and Behaviour, Radboud University,
Nijmegen, Netherlands.
(4)Institute for Physiological Chemistry, University Medical Center of the
Johannes Gutenberg-University Mainz, Anselm-Franz-von-Bentzel-Weg 3, 55128
Mainz, Germany; Institute of Experimental Epileptology and Cognition Research,
University of Bonn, Venusberg-Campus 1, 53127 Bonn, Germany. Electronic address:
.
Recent advances in experimental techniques provide an unprecedented peek into
the intricate molecular dynamics inside synapses and dendrites. The experimental
insights into the molecular turnover revealed that such processes as diffusion,
active transport, spine uptake, and local protein synthesis could dynamically
modulate the copy numbers of plasticity-related molecules in synapses.
Subsequently, theoretical models were designed to understand the interaction of
these processes better and to explain how local synaptic plasticity cues can up
or down-regulate the molecular copy numbers across synapses. In this review, we
discuss the recent advances in experimental techniques and computational models
to highlight how these complementary approaches can provide insight into
molecular cross-talk across synapses, ultimately allowing us to develop
biologically-inspired neural network models to understand brain function.
Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.
DOI: 10.1016/j.mcn.2023.103846
PMCID: PMC10274545
PMID: 36963534 [Indexed for MEDLINE]
Conflict of interest statement: Declaration of competing interest None.