Comparison of relative areas of interest between major depression disorder and postpartum depression
Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2023-03-01; 121: 110671
DOI: 10.1016/j.pnpbp.2022.110671
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1. Prog Neuropsychopharmacol Biol Psychiatry. 2023 Mar 8;121:110671. doi:
10.1016/j.pnpbp.2022.110671. Epub 2022 Oct 29.
Comparison of relative areas of interest between major depression disorder and
postpartum depression.
Gauld C(1), Pignon B(2), Fourneret P(3), Dubertret C(4), Tebeka S(4).
Author information:
(1)Department of Psychopathology of Child and Adolescent Development, Hospices
Civils de Lyon, Lyon 1, France; UMR CNRS 8590 IHPST, Sorbonne University, Paris
1, France. Electronic address: .
(2)Univ Paris-Est-Créteil (UPEC), AP-HP, Hôpitaux Universitaires « H. Mondor »,
France; DMU IMPACT, INSERM, IMRB, Translational Neuropsychiatry, Fondation
FondaMental, F-94010 Creteil, France.
(3)Department of Psychopathology of Child and Adolescent Development, Hospices
Civils de Lyon, Lyon 1, France; Marc Jeannerod Institute of Cognitive Sciences
UMR 5229, CNRS & Claude Bernard University, Lyon 1, France.
(4)Université de Paris, INSERM UMR1266, Institute of Psychiatry and
Neurosciences, Team 1, Paris, France; Department of Psychiatry, AP-HP, Louis
Mourier Hospital, F-92700 Colombes, France.
INTRODUCTION: Postpartum depression (PPD) is defined as a major depressive
disorder (MDD) beginning after childbirth. Wide debates aim to better understand
PPD’s specificities compared with MDD. One of the keys in differentiating PPD
from MDD is to systematically study scientific « Areas Of Interest » (AOIs) of
these disorders.
METHODS: In November 2021, we performed an extraction and textual computational
analysis of associated terms for PPD and MDD, using the biomedical database
PubMed. We performed an undirected lexical network analysis to map the 150 first
terms in space. Then, we used an unsupervised machine learning technique to
detect word patterns and automatically cluster AOIs with a topic-modeling
analysis.
RESULTS: We identified 30,000 articles of the 554,724 articles for MDD and
15,642 articles for PPD. Four AOIs were detected in the MDD network: mood
disorders and their treatments, risk factors, consequences and quality of life,
and mental health and comorbidities. Five AOIs were detected in the PPD network:
mood disorders and treatments, risk factors, consequences and child health,
patient’s background, and the challenges of screening.
DISCUSSION AND CONCLUSION: Limitations are both methodological, in particular
due to the qualitative interpretation of AOIs, and are also related to the
difficult transferability of these research results to the clinical practice.
The partial overlap between AOIs for MDD and for PPD suggest that the latter is
a particular form of the former.
Copyright © 2022 Elsevier Inc. All rights reserved.
DOI: 10.1016/j.pnpbp.2022.110671
PMID: 36341842 [Indexed for MEDLINE]
Conflict of interest statement: Declaration of Competing Interest None of the
authors have any competing interests.