Comparison of fat storage between Fischer 344 and obesity-resistant Lou/C rats fed different diets.

Jean-Marie Héliès, Abdoulaye Diane, Allan Langlois, Christiane Larue-Achagiotis, Gilles Fromentin, Daniel Tomé, Pierre Mormède, Nathalie Marissal-Arvy
Obesity Research. 2005-01-01; 13(1): 3-10
DOI: 10.1038/oby.2005.3

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1. Obes Res. 2005 Jan;13(1):3-10.

Comparison of fat storage between Fischer 344 and obesity-resistant Lou/C rats
fed different diets.

Héliès JM(1), Diane A, Langlois A, Larue-Achagiotis C, Fromentin G, Tomé D,
Mormède P, Marissal-Arvy N.

Author information:
(1)Laboratory for Neurogenetics and Stress, UMR 1243 INRA, Université Victor
Segalen Bordeaux 2, Bordeaux cedex, France.

OBJECTIVE: We aimed to characterize further the Lou/C (LOU) and Fischer 344
(F344) rat strains for nutritional traits to validate their use as contrasting
strains for molecular genetic studies.
RESEARCH METHODS AND PROCEDURES: Five batches of LOU and F344 rats were used to
measure caloric intake, weight gain, and body composition when fed a chow diet, a
self-selection diet (together with the study of preferences for macronutrients),
hypercaloric diets, and a chow diet in a cold environment.
RESULTS: Despite a higher caloric intake when fed a chow diet, LOU rats showed a
lower weight gain, final body weight, and percentage of fat tissue, together with
a higher percentage of carcass weight, than F344 rats. When fed a self-selection
diet, LOU males ingested less protein and more fat than F344 males, and the
reverse was observed for females. In this condition, feed efficiency was reduced
in LOU but increased in F344 rats compared with the chow diet. Diet-induced
obesity was observed in F344 rats but not in LOU rats fed hypercaloric diets. In
a cold environment, both LOU and F344 rats displayed an increased percentage of
brown adipose tissue compared with control groups, together with a higher caloric
DISCUSSION: The study shows robust nutritional differences between the LOU rat, a
lean strain with a low feed efficiency and resistant to diet-induced obesity, and
the contrasting F344 rat strain. It also shows the interest in these strains for
studying the genetic components of resistance to obesity.

DOI: 10.1038/oby.2005.3
PMID: 15761158 [Indexed for MEDLINE]

Auteurs Bordeaux Neurocampus