Comparison of cAMP-specific phosphodiesterase mRNAs distribution in mouse and rat brain
Neuroscience Letters. 2012-09-01; 525(1): 1-6
DOI: 10.1016/j.neulet.2012.07.050
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There are eleven families of phosphodiesterases that regulate cellular levels of
cyclic nucleotides by degradation of cAMP or cGMP. Knowledge of the expression
sites of different PDE genes in brain is of special importance for studies on
development of specific inhibitors considering that, for example, PDE4 inhibitor
treatments exhibit profound anti-inflammatory effects. To address possible
species differences we examined the expression of mRNAs coding for the cAMP
specific PDE4 and PDE7 families since inhibitors have been used in clinic for
schizophrenia, mood disorders, cognition and inflammatory diseases treatment. We
have compared the expression of these PDEs in mouse brain by in situ
hybridization histochemistry in comparison with rat brain and found that their
neuroanatomical distribution differs in a few areas.
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