Cognitive impairment differs between primary progressive and relapsing-remitting MS.
Neurology. 2013-04-16; 80(16): 1501-1508
DOI: 10.1212/wnl.0b013e31828cf82f
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1. Neurology. 2013 Apr 16;80(16):1501-8. doi: 10.1212/WNL.0b013e31828cf82f. Epub
2013 Mar 20.
Cognitive impairment differs between primary progressive and relapsing-remitting
MS.
Ruet A(1), Deloire M, Charré-Morin J, Hamel D, Brochet B.
Author information:
(1)Université de Bordeaux, INSERM-CHU CIC-P 0005, and Service de Neurologie,
Bordeaux, France.
OBJECTIVES: To characterize the cognitive abilities of patients with primary
progressive multiple sclerosis (PPMS) and relapsing-remitting multiple sclerosis
(RRMS) compared with healthy controls (HCs) matched for age, sex, and education
level while considering the different characteristics of PPMS and RRMS and to
compare the cognitive patterns of these types of multiple sclerosis.
METHODS: Forty-one patients with PPMS, 60 patients with RRMS, and 415 HCs were
recruited in a cross-sectional study. Controls were divided into 20 groups
according to age, sex, and education level. Participants were assessed with a
large battery of neuropsychological (NP) tests that included a modified version
of the Brief Repeatable Battery, the Stroop test, computerized tests from the
Test of Attentional Performance battery, the numerical span test, and the Rey
Complex Figure.
RESULTS: Patients with PPMS performed worse than their matched HCs on nearly all
NP tests. Patients with RRMS performed worse than matched HCs on a computerized
digit-symbol substitution task and the alertness test, reaction time for visual
scanning, and Paced-Auditory Serial Addition Test-3 seconds. Patients with PPMS
had worse NP scores and were more impaired in cognitive domains than patients
with RRMS. After controlling for Expanded Disability Status Scale score, the
results remained unchanged.
CONCLUSION: The patients with PPMS presented with a wide range of cognitive
deficits in information processing speed, attention, working memory, executive
function, and verbal episodic memory, whereas the impairments in patients with
RRMS were limited to information processing speed and working memory compared
with their matched HCs. Cognitive deficits were more severe in patients with
PPMS than in patients with RRMS.
DOI: 10.1212/WNL.0b013e31828cf82f
PMID: 23516324 [Indexed for MEDLINE]