Cocaine-evoked negative symptoms require AMPA receptor trafficking in the lateral habenula.
Nat Neurosci. 2015-02-02; 18(3): 376-378
DOI: 10.1038/nn.3923
Lire sur PubMed
1. Nat Neurosci. 2015 Mar;18(3):376-8. doi: 10.1038/nn.3923. Epub 2015 Feb 2.
Cocaine-evoked negative symptoms require AMPA receptor trafficking in the lateral
habenula.
Meye FJ(1), Valentinova K(1), Lecca S(1), Marion-Poll L(1), Maroteaux MJ(1),
Musardo S(2), Moutkine I(1), Gardoni F(2), Huganir RL(3), Georges F(4), Mameli
M(1).
Author information:
(1)1] Institut du Fer à Moulin, Paris, France. [2] Inserm, UMR-S 839, Paris,
France. [3] Université Pierre et Marie Curie, Paris, France.
(2)DiSFeB, Dipartimento di Scienze Farmacologiche e Biomolecolari, Università
degli Studi di Milano, Milano, Italy.
(3)Solomon H. Snyder Department of Neuroscience, The Johns Hopkins University
School of Medicine, Baltimore, Maryland, USA.
(4)1] Centre National de la Recherche Scientifique, Interdisciplinary Institute
for Neuroscience, UMR 5297, Bordeaux, France. [2] Université de Bordeaux,
Bordeaux, France.
Comment in
Nat Neurosci. 2016 Jul 26;19(8):981-3.
Addictive substances mediate positive and negative states promoting persistent
drug use. However, substrates for aversive effects of drugs remain elusive. We
found that, in mouse lateral habenula (LHb) neurons targeting the rostromedial
tegmental nucleus, cocaine enhanced glutamatergic transmission, reduced K(+)
currents and increased excitability. GluA1 trafficking in LHb was instrumental
for these cocaine-evoked modifications and drug-driven aversive behaviors.
Altogether, our results suggest that long-lasting adaptations in LHb shape
negative symptoms after drug taking.
DOI: 10.1038/nn.3923
PMCID: PMC4357267
PMID: 25643299 [Indexed for MEDLINE]