Cloning and Selective Expression in Brain and Kidney of ARNT2 Homologous to the Ah Receptor Nuclear Translocator (ARNT)
Biochemical and Biophysical Research Communications. 1996-08-01; 225(2): 333-339
DOI: 10.1006/bbrc.1996.1176
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1. Biochem Biophys Res Commun. 1996 Aug 14;225(2):333-9. doi:
10.1006/bbrc.1996.1176.
Cloning and selective expression in brain and kidney of ARNT2 homologous to the
Ah receptor nuclear translocator (ARNT).
Drutel G(1), Kathmann M, Heron A, Schwartz JC, Arrang JM.
Author information:
(1)Unité de Neurobiologie et Pharmacologie (U.109) de l’INSERM, Centre Paul
Broca, Paris, France.
Arnt2, a new member of the basic-helix-loop-helix transcription factor family,
was cloned from rat brain cDNAs. Its deduced 712 amino acid sequence displays
63% identity with that of the aryl hydrocarbon receptor nuclear translocator
(Arnt1) that was completely established. Whereas Arnt2 gene expression,
established by Northern blotting and in situ hybridization histochemistry,
occurred selectively in brain and kidney, that of Arnt1 was ubiquitous,
suggesting that the two proteins play distinct roles, presumably via
dimerization and DNA binding with different partners.
DOI: 10.1006/bbrc.1996.1176
PMID: 8753765 [Indexed for MEDLINE]