Clinical and MRI findings in spinocerebellar ataxia type 5.
Neurology. 1999-10-01; 53(6): 1355-1355
DOI: 10.1212/WNL.53.6.1355
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1. Neurology. 1999 Oct 12;53(6):1355-7.
Clinical and MRI findings in spinocerebellar ataxia type 5.
Stevanin G(1), Herman A, Brice A, Dürr A.
Author information:
(1)INSERM U289, Hôpital de la Salpêtrière, Paris, France.
Spinocerebellar ataxia type 5 (SCA5), one of the genetically heterogeneous
autosomal dominant cerebellar ataxias, was assigned to chromosome 11 in a single
family descending from the grandparents of President Abraham Lincoln. We report a
second, apparently unrelated, SCA5 family of French origin. The overall clinical
picture was a slowly progressive cerebellar syndrome beginning mostly in the
third decade (27+/-10 years, range 14 to 40). MRI showed a marked global
cerebellar atrophy similar to SCA6.
DOI: 10.1212/wnl.53.6.1355
PMID: 10522902 [Indexed for MEDLINE]