Chronic treatment with systemic morphine induced tolerance to the systemic and peripheral antinociceptive effects of morphine on both carrageenin induced mechanical hyperalgesia and spinal c-Fos expression in awake rats.

Prisca Honoré, Gwenaëlle Catheline, Stéphanie Le Guen, Jean-Marie Besson
Pain. 1997-05-01; 71(1): 99-108
DOI: 10.1016/s0304-3959(97)03345-9

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Auteurs Bordeaux Neurocampus