Chromosome evolution of MMU16 and RNO11: conserved synteny associated with gene order rearrangements explicable by intrachromosomal recombinations and neocentromere emergence.
Cytogenet Genome Res. 2004-12-13; 108(4): 322-327
DOI: 10.1159/000081526
Lire sur PubMed
1. Cytogenet Genome Res. 2005;108(4):322-7.
Chromosome evolution of MMU16 and RNO11: conserved synteny associated with gene
order rearrangements explicable by intrachromosomal recombinations and
neocentromere emergence.
Szpirer C(1), Rivière M, VanVooren P, Moisan MP, Haller O, Szpirer J.
Author information:
(1)IBMM, Université libre de Bruxelles, Gosselies, Charleroi, Belgium.
Comparative mapping between the rat and mouse genomes has shown that some
chromosomes are entirely or almost entirely conserved with respect to gene
content. Such is the case of rat chromosome 11 (RNO11) and mouse chromosome 16
(MMU16). We determined to what extent such an extensive conservation of synteny
is associated with a conserved gene order. Therefore, we regionally localized
several genes on RNO11. The comparison of the gene map of RNO11 and MMU16
unambiguously shows that the gene order has not been conserved in the Murinae
lineage, thereby implying the occurrence of intrachromosomal evolutionary
rearrangements. The transition from one chromosome configuration to the other one
can be explained either by two intrachromosomal recombinations or by a single
intrachromosomal recombination accompanied by neocentromere emergence.
Copyright 2005 S. Karger AG, Basel.
DOI: 10.1159/000081526
PMID: 15627752 [Indexed for MEDLINE]